After Man.
It's 2002, and a plague of unknown origin has killed all of the male mammals on Earth – all except an amateur escape artist named Yorick Brown and his surly helper monkey, Ampersand.
As the last remaining Y-chromosome carriers on the planet, Yorick and his pet hold the fate of humanity in their hands. To ensure the survival of the species, they've teamed up with a gun-toting government agent and the world's premier bioengineer to discover the secret behind the plague. But while they ride the rails across a radically transformed America, the man-hating Daughters of the Amazon are right behind them – and an unplanned stopover in the seemingly utopian town of Marrisville, Ohio may mean the end of the line for the Last Man.